PDF DatasheetHuman GATE-16 / GABARAPL2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant GATE-16 / GABARAPL2 based upon sequence from: Human
Host: QP8448 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) GATE-16 / GABARAPL2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8448.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Phe117
Amino Acid Sequence: MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GATE-16 / GABARAPL2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human GATE-16 / GABARAPL2 Protein General Information | |
|---|---|
| Alternate Names | |
| GATE-16; GABARAPL2; GEF2; GATE-16; GEF-2; ATG8; ATG8C; GATE16 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GABARAPL2 |
| Entrez Gene ID | 11345 |
| Ensemble Gene ID | ENSG00000034713 |
| RefSeq Protein Accession(s) | NP_009216.1 |
| RefSeq mRNA Accession(s) | NM_007285.6 |
| UniProt ID(s) | P60520 |
| UniGene ID(s) | Hs.461379 |
| HGNC ID(s) | HGNC:13291 |
| COSMIC ID Link(s) | GABARAPL2 |
| KEGG Gene ID(s) | hsa:11345 |
| PharmGKB ID(s) | PA28482 |
| General Description of Recombinant Human GATE-16 / GABARAPL2 Protein. | |
| Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 . Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirents and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore mbrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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