PDF DatasheetHuman Negative elongation factor B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Negative elongation factor B based upon sequence from: Human
Host: QP8455 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Negative elongation factor B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8455.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu8 – Glu199
Amino Acid Sequence: LGVANGEDLK ETLTNCTEPL KAIEQFQTEN GVLLPSLQSA LPFLDLHGTP RLEFHQSVFD ELRDKLLERV SAIASEGKAE ERYKKLEDLL EKSFSLVKMP SLQPVVMCVM KHLPKVPEKK LKLVMADKEL YRACAVEVKR QIWQDNQALF GDEVSPLLKQ YILEKESALF STELSVLHNF FSPSPKTRRQ GE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Negative elongation factor B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Negative elongation factor B Protein General Information | |
|---|---|
| Alternate Names | |
| NELF-B; COBRA1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COBRA1 |
| Entrez Gene ID | 25920 |
| Ensemble Gene ID | ENSG00000188986 |
| RefSeq Protein Accession(s) | NP_056271.3 |
| RefSeq mRNA Accession(s) | NM_015456.4 |
| UniProt ID(s) | Q8WX92 |
| UniGene ID(s) | Hs.521809 |
| HGNC ID(s) | HGNC:24324 |
| COSMIC ID Link(s) | COBRA1 |
| KEGG Gene ID(s) | hsa:25920 |
| PharmGKB ID(s) | PA162382703 |
| General Description of Recombinant Human Negative elongation factor B Protein. | |
| Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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