PDF DatasheetHuman G-protein coupled receptor 161 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant G-protein coupled receptor 161 based upon sequence from: Human
Host: QP8467 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) G-protein coupled receptor 161, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8467.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ile28
Amino Acid Sequence: MSLNSSLSCR KELSNLTEEE GGEGGVII
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human G-protein coupled receptor 161 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human G-protein coupled receptor 161 Protein General Information | |
|---|---|
| Alternate Names | |
| RE2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GPR161 |
| Entrez Gene ID | 23432 |
| Ensemble Gene ID | ENSG00000143147 |
| RefSeq Protein Accession(s) | NP_001254538.1 |
| RefSeq mRNA Accession(s) | NM_001267609.1, NM_001267610.1, NM_001267612.1, NM_001267613.1, NM_001267614.1, NM_153832.2, XM_005245055.2, XM_005245056.2, XM_005245057.4, XM_011509375.2, XM_011509376.2, XM_011509377.1, XM_011509378.1, XM_017000859.1, XM_017000860.1, XM_017000861.1, XM_017000862.1 |
| UniProt ID(s) | Q8N6U8 |
| UniGene ID(s) | Hs.271809 |
| HGNC ID(s) | HGNC:23694 |
| COSMIC ID Link(s) | GPR161 |
| KEGG Gene ID(s) | hsa:23432 |
| PharmGKB ID(s) | PA134931474 |
| General Description of Recombinant Human G-protein coupled receptor 161 Protein. | |
| Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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