PDF DatasheetHuman Profilin-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Profilin-1 based upon sequence from: Human
Host: QP8469 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Profilin-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8469.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Tyr140
Amino Acid Sequence: AGWNAYIDNL MADGTCQDAA IVGYKDSPSV WAAVPGKTFV NITPAEVGVL VGKDRSSFYV NGLTLGGQKC SVIRDSLLQD GEFSMDLRTK STGGAPTFNV TVTKTDKTLV LLMGKEGVHG GLINKKCYEM ASHLRRSQY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Profilin-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Profilin-1 Protein General Information | |
|---|---|
| Alternate Names | |
| ALS18 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PFN1 |
| Entrez Gene ID | 5216 |
| Ensemble Gene ID | ENSG00000108518 |
| RefSeq Protein Accession(s) | NP_005013.1 |
| RefSeq mRNA Accession(s) | NM_005022.3 |
| UniProt ID(s) | P07737 |
| UniGene ID(s) | Hs.494691 |
| HGNC ID(s) | HGNC:8881 |
| COSMIC ID Link(s) | PFN1 |
| KEGG Gene ID(s) | hsa:5216 |
| PharmGKB ID(s) | PA33219 |
| General Description of Recombinant Human Profilin-1 Protein. | |
| Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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