PDF DatasheetHuman Breast cancer metastasis-suppressor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Breast cancer metastasis-suppressor 1 based upon sequence from: Human
Host: QP8482 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Breast cancer metastasis-suppressor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8482.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ala235
Amino Acid Sequence: MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Breast cancer metastasis-suppressor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Breast cancer metastasis-suppressor 1 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BRMS1 |
| Entrez Gene ID | 25855 |
| Ensemble Gene ID | ENSG00000174744 |
| RefSeq Protein Accession(s) | NP_056214.1 |
| RefSeq mRNA Accession(s) | NM_015399.3 |
| UniProt ID(s) | Q9HCU9 |
| UniGene ID(s) | Hs.100426 |
| HGNC ID(s) | HGNC:17262 |
| COSMIC ID Link(s) | BRMS1 |
| KEGG Gene ID(s) | hsa:25855 |
| PharmGKB ID(s) | PA164741342 |
| General Description of Recombinant Human Breast cancer metastasis-suppressor 1 Protein. | |
| Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at ‘Lys-310’. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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