PDF DatasheetHuman Programmed cell death protein 6 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Programmed cell death protein 6 based upon sequence from: Human
Host: QP8484 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Programmed cell death protein 6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8484.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val191
Amino Acid Sequence: MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Programmed cell death protein 6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Programmed cell death protein 6 Protein General Information | |
|---|---|
| Alternate Names | |
| ALG2; PEF1B; ALG-2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ALG2 |
| Entrez Gene ID | 10016 |
| Ensemble Gene ID | ENSG00000249915 |
| RefSeq Protein Accession(s) | NP_001254485.1 |
| RefSeq mRNA Accession(s) | NM_001267556.1, NM_001267557.1, NM_001267558.1, NM_001267559.1, NM_013232.3 |
| UniProt ID(s) | O75340 |
| UniGene ID(s) | Hs.50823 |
| HGNC ID(s) | HGNC:8765 |
| COSMIC ID Link(s) | ALG2 |
| KEGG Gene ID(s) | hsa:10016 |
| PharmGKB ID(s) | PA33115 |
| General Description of Recombinant Human Programmed cell death protein 6 Protein. | |
| Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway . Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Ses to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca2+ affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.5 Publications | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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