PDF DatasheetHuman Protein AATF Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein AATF based upon sequence from: Human
Host: QP8502 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein AATF, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8502.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Pro6 – Glu294
Amino Acid Sequence: PLALQLEQLL NPRPSEADPE ADPEEATAAR VIDRFDEGED GEGDFLVVGS IRKLASASLL DTDKRYCGKT TSRKAWNEDH WEQTLPGSSD EEISDEEGSG DEDSEGLGLE EYDEDDLGAA EEQECGDHRE SKKSRSHSAK TPGFSVQSIS DFEKFTKGMD DLGSSEEEED EESGMEEGDD AEDSQGESEE DRAGDRNSED DGVVMTFSSV KVSEEVEKGR AVKNQIALWD QLLEGRIKLQ KALLTTNQLP QPDVFPLFKD KGGPEFSSAL KNSHKALKAL LRSLVGLQE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein AATF Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein AATF Protein General Information | |
|---|---|
| Alternate Names | |
| CHE-1; BFR2; CHE1; DED | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AATF |
| Entrez Gene ID | 26574 |
| Ensemble Gene ID | ENSG00000275700 |
| RefSeq Protein Accession(s) | NP_036270.1 |
| RefSeq mRNA Accession(s) | NM_012138.3 |
| UniProt ID(s) | Q9NY61 |
| UniGene ID(s) | Hs.195740 |
| HGNC ID(s) | HGNC:19235 |
| KEGG Gene ID(s) | hsa:26574 |
| PharmGKB ID(s) | PA128395780 |
| General Description of Recombinant Human Protein AATF Protein. | |
| May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacent of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dentia), although the molecular basis for this phenomenon has not been described to date. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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