PDF DatasheetHuman Rho guanine nucleotide exchange factor 18 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Rho guanine nucleotide exchange factor 18 based upon sequence from: Human
Host: QP8503 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Rho guanine nucleotide exchange factor 18, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8503.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met159 – Leu551
Amino Acid Sequence: MTVSQKGGPQ PTPSPAGPGT QLGPITGEMD EADSAFLKFK QTADDSLSLT SPNTESIFVE DPYTASLRSE IESDGHEFEA ESWSLAVDAA YAKKQKREVV KRQDVLYELM QTEVHHVRTL KIMLKVYSRA LQEELQFSSK AIGRLFPCAD DLLETHSHFL ARLKERRQES LEEGSDRNYV IQKIGDLLVQ QFSGENGERM KEKYGVFCSG HNEAVSHYKL LLQQNKKFQN LIKKIGNFSI VRRLGVQECI LLVTQRITKY PVLVERIIQN TEAGTEDYED LTQALNLIKD IISQVDAKVS ECEKGQRLRE IAGKMDLKSS SKLKNGLTFR KEDMLQRQLH LEGMLCWKTT SGRLKDILAI LLTDVLLLLQ EKDQKYVFAS VDSKPPVISL QKL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Rho guanine nucleotide exchange factor 18 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Rho guanine nucleotide exchange factor 18 Protein General Information | |
|---|---|
| Alternate Names | |
| P114-RhoGEF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ARHGEF18 |
| Entrez Gene ID | 23370 |
| Ensemble Gene ID | ENSG00000104880 |
| RefSeq Protein Accession(s) | NP_001124427.1 |
| RefSeq mRNA Accession(s) | NM_001130955.1, NM_015318.3, XM_006722708.2, XM_011527840.1 |
| UniProt ID(s) | Q6ZSZ5 |
| UniGene ID(s) | Hs.465761 |
| HGNC ID(s) | HGNC:17090 |
| COSMIC ID Link(s) | ARHGEF18 |
| KEGG Gene ID(s) | hsa:23370 |
| PharmGKB ID(s) | PA128394630 |
| General Description of Recombinant Human Rho guanine nucleotide exchange factor 18 Protein. | |
| Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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