PDF DatasheetHuman PRKCA-binding protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PRKCA-binding protein based upon sequence from: Human
Host: QP8506 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PRKCA-binding protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8506.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Gln200
Amino Acid Sequence: MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PRKCA-binding protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PRKCA-binding protein Protein General Information | |
|---|---|
| Alternate Names | |
| PICK; PRKCABP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PICK1 |
| Entrez Gene ID | 9463 |
| Ensemble Gene ID | ENSG00000100151 |
| RefSeq Protein Accession(s) | NP_001034672.1 |
| RefSeq mRNA Accession(s) | NM_001039583.1, NM_001039584.1, NM_012407.3 |
| UniProt ID(s) | Q9NRD5 |
| UniGene ID(s) | Hs.180871 |
| HGNC ID(s) | HGNC:9394 |
| COSMIC ID Link(s) | PICK1 |
| KEGG Gene ID(s) | hsa:9463 |
| PharmGKB ID(s) | PA33760 |
| General Description of Recombinant Human PRKCA-binding protein Protein. | |
| Probable adapter protein that bind to and organize the subcellular localization of a variety of mbrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.