PDF DatasheetHuman CASP3 / Caspase-3 / CASP-3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CASP3 / Caspase-3 / CASP-3 based upon sequence from: Human
Host: QP8509 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CASP3 / Caspase-3 / CASP-3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8509.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser29 – Asp175
Amino Acid Sequence: SGISLDNSYK MDYPEMGLCI IINNKNFHKS TGMTSRSGTD VDAANLRETF RNLKYEVRNK NDLTREEIVE LMRDVSKEDH SKRSSFVCVL LSHGEEGIIF GTNGPVDLKK ITNFFRGDRC RSLTGKPKLF IIQACRGTEL DCGIETD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CASP3 / Caspase-3 / CASP-3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CASP3 / Caspase-3 / CASP-3 Protein General Information | |
|---|---|
| Alternate Names | |
| CASP3; Caspase-3; CASP-3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CASP3 |
| Entrez Gene ID | 836 |
| Ensemble Gene ID | ENSG00000164305 |
| RefSeq Protein Accession(s) | NP_004337.2 |
| RefSeq mRNA Accession(s) | NM_004346.3, NM_032991.2, XM_011532301.1 |
| UniProt ID(s) | P42574 |
| UniGene ID(s) | Hs.141125 |
| HGNC ID(s) | HGNC:1504 |
| COSMIC ID Link(s) | CASP3 |
| KEGG Gene ID(s) | hsa:836 |
| PharmGKB ID(s) | PA26087 |
| General Description of Recombinant Human CASP3 / Caspase-3 / CASP-3 Protein. | |
| Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ‘216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory elent binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the mbrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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