PDF DatasheetHuman AGRP Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant AGRP based upon sequence from: Human
Host: QP8510 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) AGRP, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8510.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser83 – Thr132
Amino Acid Sequence: SSRRCVRLHE SCLGQQVPCC DPCATCYCRF FNAFCYCRKL GTAMNPCSRT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human AGRP Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human AGRP Protein (83-132aa) General Information | |
|---|---|
| Alternate Names | |
| AGRP; ART; AGRT; ASIP2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AGRP |
| Entrez Gene ID | 181 |
| Ensemble Gene ID | ENSG00000159723 |
| RefSeq Protein Accession(s) | NP_001129.1 |
| RefSeq mRNA Accession(s) | NM_001138.1 |
| UniProt ID(s) | O00253 |
| UniGene ID(s) | Hs.104633 |
| HGNC ID(s) | HGNC:330 |
| COSMIC ID Link(s) | AGRP |
| KEGG Gene ID(s) | hsa:181 |
| PharmGKB ID(s) | PA24627 |
| General Description of Recombinant Human AGRP Protein (83-132aa). | |
| Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin syst. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R . Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.5 Publications | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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