PDF DatasheetHuman Angiogenin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Angiogenin based upon sequence from: Human
Host: QP8511 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Angiogenin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8511.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Asp26 – Pro147
Amino Acid Sequence: DNSRYTHFLT QHYDAKPQGR DDRYCESIMR RRGLTSPCKD INTFIHGNKR SIKAICENKN GNPHRENLRI SKSSFQVTTC KLHGGSPWPP CQYRATAGFR NVVVACENGL PVHLDQSIFR RP
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Angiogenin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Angiogenin Protein General Information | |
|---|---|
| Alternate Names | |
| RAA1; HEL168; ALS9; RNASE4; RNASE5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RNASE5 |
| Entrez Gene ID | 283 |
| Ensemble Gene ID | ENSG00000214274 |
| RefSeq Protein Accession(s) | NP_001091046.1 |
| RefSeq mRNA Accession(s) | NM_001097577.2, NM_001145.4 |
| UniProt ID(s) | P03950 |
| UniGene ID(s) | Hs.283749 |
| HGNC ID(s) | HGNC:483 |
| KEGG Gene ID(s) | hsa:283 |
| PharmGKB ID(s) | PA24790 |
| General Description of Recombinant Human Angiogenin Protein. | |
| Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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