PDF DatasheetHuman Caspase-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Caspase-1 based upon sequence from: Human
Host: QP8518 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Caspase-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8518.
Bioactivity Data: Customers have reported this protein has no activity.
Full Length? Partial (see sequence information for more details).
Expression Region: Asn120 – Asn269
Amino Acid Sequence: NPAMPTSSGS EGNVKLCSLE EAQRIWKQKS AEIYPIMDKS SRTRLALIIC NEEFDSIPRR TGAEVDITGM TMLLQNLGYS VDVKKNLTAS DMTTELEAFA HRPEHKTSDS TFLVFMSHGI REGICGKKHS EQVPDILQLN AIFNMLNTKN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Caspase-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Caspase-1 Protein General Information | |
|---|---|
| Alternate Names | |
| IL1BC; ICE; P45 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CASP1 |
| Entrez Gene ID | 834 |
| Ensemble Gene ID | ENSG00000137752 |
| RefSeq Protein Accession(s) | NP_001214.1 |
| RefSeq mRNA Accession(s) | NM_001223.4, NM_001257118.2, NM_001257119.2, NM_033292.3, NM_033293.3, NM_033294.3, NM_033295.3 |
| UniProt ID(s) | P29466 |
| UniGene ID(s) | Hs.2490 |
| HGNC ID(s) | HGNC:1499 |
| COSMIC ID Link(s) | CASP1 |
| KEGG Gene ID(s) | hsa:834 |
| PharmGKB ID(s) | PA26083 |
| General Description of Recombinant Human Caspase-1 Protein. | |
| Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory elent binding proteins (SREBPs). Can also promote apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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