PDF DatasheetHuman DKK-1 / Dkk1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DKK-1 / Dkk1 based upon sequence from: Human
Host: QP8536 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DKK-1 / Dkk1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8536.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu33 – His2
Amino Acid Sequence: LNSVLNSNAI KNLPPPLGGA AGHPGSAVSA APGILYPGGN KYQTIDNYQP YPCAEDEECG TDEYCASPTR GGDAGVQICL ACRKRRKRCM RHAMCCPGNY CKNGICVSSD QNHFRGEIEE TITESFGNDH STLDGYSRRT TLSSKMYHTK GQEGSVCLRS SDCASGLCCA RHFWSKICKP VLKEGQVCTK HRRKGSHGLE IFQRCYCGEG LSCRIQKDHH QASNSSRLHT CQRH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DKK-1 / Dkk1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DKK-1 / Dkk1 Protein General Information | |
|---|---|
| Alternate Names | |
| DKK-1; Dkk1; DKK-1; SK | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DKK1 |
| Entrez Gene ID | 22943 |
| Ensemble Gene ID | ENSG00000107984 |
| RefSeq Protein Accession(s) | NP_036374.1 |
| RefSeq mRNA Accession(s) | NM_012242.2 |
| UniProt ID(s) | O94907 |
| UniGene ID(s) | Hs.40499 |
| HGNC ID(s) | HGNC:2891 |
| COSMIC ID Link(s) | DKK1 |
| KEGG Gene ID(s) | hsa:22943 |
| PharmGKB ID(s) | PA27345 |
| General Description of Recombinant Human DKK-1 / Dkk1 Protein. | |
| Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmbrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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