PDF DatasheetHuman SNCA / alpha-Synuclein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SNCA / alpha-Synuclein based upon sequence from: Human
Host: QP8563 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SNCA / alpha-Synuclein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8563.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Glu139
Amino Acid Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human SNCA / alpha-Synuclein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SNCA / alpha-Synuclein Protein General Information | |
|---|---|
| Alternate Names | |
| SNCA; alpha-Synuclein; PD1; NACP; PARK1; PARK4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Snca |
| Entrez Gene ID | 6622 |
| Ensemble Gene ID | ENSG00000145335 |
| RefSeq Protein Accession(s) | NP_000336.1 |
| RefSeq mRNA Accession(s) | NM_000345.3, NM_001146054.1, NM_001146055.1, NM_007308.2, XM_011532208.2, XM_017008562.1, XM_017008563.1 |
| UniProt ID(s) | P37840 |
| UniGene ID(s) | Hs.21374 |
| HGNC ID(s) | HGNC:11138 |
| COSMIC ID Link(s) | SNCA |
| KEGG Gene ID(s) | hsa:6622 |
| PharmGKB ID(s) | PA35986 |
| General Description of Recombinant Human SNCA / alpha-Synuclein Protein. | |
| May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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