PDF DatasheetHuman Glucagon Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Glucagon based upon sequence from: Human
Host: QP8639 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glucagon, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8639.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: His53 – Ala89
Amino Acid Sequence: HSQGTFTSDY SKYLDSRRAQ DFVQWLMNTK RNRNNIA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Glucagon Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Glucagon Protein General Information | |
|---|---|
| Alternate Names | |
| GLP1; GRPP; GLP2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GCG |
| Entrez Gene ID | 2641 |
| Ensemble Gene ID | ENSG00000115263 |
| RefSeq Protein Accession(s) | NP_002045.1 |
| RefSeq mRNA Accession(s) | NM_002054.4 |
| UniProt ID(s) | P01275 |
| UniGene ID(s) | Hs.516494 |
| HGNC ID(s) | HGNC:4191 |
| COSMIC ID Link(s) | GCG |
| KEGG Gene ID(s) | hsa:2641 |
| PharmGKB ID(s) | PA28606 |
| General Description of Recombinant Human Glucagon Protein. | |
| Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycia. Plays an important role in initiating and maintaining hyperglycic conditions in diabetes.GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.Oxyntomodulin significantly reduces food intake. Inhibits gastric ptying in humans. Suppression of gastric ptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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