Human 14-3-3 beta / YWHAB Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant 14-3-3 beta / YWHAB based upon sequence from: Human
Host: QP867 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) 14-3-3 beta / YWHAB, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP867.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn246
Amino Acid Sequence: MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human 14-3-3 beta / YWHAB Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
Recombinant Human 14-3-3 beta / YWHAB Protein General Information | |
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Alternate Names | |
14-3-3 beta, YWHAB, YWHAA, HS1, GW128, KCIP-1, HEL-S-1 | |
Curated Database and Bioinformatic Data | |
Gene Symbol | YWHAB |
Entrez Gene ID | 7529 |
Ensemble Gene ID | ENSG00000166913 |
RefSeq Protein Accession(s) | NP_003395.1 |
RefSeq mRNA Accession(s) | NM_003404.4, NM_139323.3, XM_017028039.1 |
UniProt ID(s) | P31946 |
UniGene ID(s) | Hs.643544 |
HGNC ID(s) | HGNC:12849 |
COSMIC ID Link(s) | YWHAB |
KEGG Gene ID(s) | hsa:7529 |
PharmGKB ID(s) | PA37438 |
General Description of Recombinant Human 14-3-3 beta / YWHAB Protein. | |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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