PDF DatasheetHuman HER2 / ErbB2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HER2 / ErbB2 based upon sequence from: Human
Host: QP8675 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HER2 / ErbB2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8675.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val153 – Ala598
Amino Acid Sequence: VLIQRNPQLC YQDTILWKDI FHKNNQLALT LIDTNRSRAC HPCSPMCKGS RCWGESSEDC QSLTRTVCAG GCARCKGPLP TDCCHEQCAA GCTGPKHSDC LACLHFNHSG ICELHCPALV TYNTDTFESM PNPEGRYTFG ASCVTACPYN YLSTDVGSCT LVCPLHNQEV TAEDGTQRCE KCSKPCARVC YGLGMEHLRE VRAVTSANIQ EFAGCKKIFG SLAFLPESFD GDPASNTAPL QPEQLQVFET LEEITGYLYI SAWPDSLPDL SVFQNLQVIR GRILHNGAYS LTLQGLGISW LGLRSLRELG SGLALIHHNT HLCFVHTVPW DQLFRNPHQA LLHTANRPED ECVGEGLACH QLCARGHCWG PGPTQCVNCS QFLRGQECVE ECRVLQGLPR EYVNARHCLP CHPECQPQNG SVTCFGPEAD QCVACAHYKD PPFCVA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human HER2 / ErbB2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HER2 / ErbB2 Protein (153-598aa) General Information | |
|---|---|
| Alternate Names | |
| HER2; ErbB2; Erbb-2; Neu; HER2; l11Jus8; HER-2; c-erbB2; mKIAA3023; c-neu | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ERBB2 |
| Entrez Gene ID | 2064 |
| Ensemble Gene ID | ENSG00000141736 |
| RefSeq Protein Accession(s) | NP_001005862.1 |
| RefSeq mRNA Accession(s) | NM_001005862.2, NM_001289936.1, NM_001289938.1, NM_004448.3 |
| UniProt ID(s) | P04626 |
| UniGene ID(s) | Hs.446352 |
| HGNC ID(s) | HGNC:3430 |
| COSMIC ID Link(s) | ERBB2 |
| KEGG Gene ID(s) | hsa:2064 |
| PharmGKB ID(s) | PA27844 |
| General Description of Recombinant Human HER2 / ErbB2 Protein (153-598aa). | |
| Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell mbrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell mbrane. In turn, mbrane-bound APC allows the localization of MACF1 to the cell mbrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5′-TCAAATTC-3′ sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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