PDF DatasheetHuman ANGPTL4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ANGPTL4 based upon sequence from: Human
Host: QP8682 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ANGPTL4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8682.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val28 – Glu403
Amino Acid Sequence: VQSKSPRFAS WDEMNVLAHG LLQLGQGLRE HAERTRSQLS ALERRLSACG SACQGTEGST DLPLAPESRV DPEVLHSLQT QLKAQNSRIQ QLFHKVAQQQ RHLEKQHLRI QHLQSQFGLL DHKHLDHEVA KPARRKRLPE MAQPVDPAHN VSRLHRLPRD CQELFQVGER QSGLFEIQPQ GSPPFLVNCK MTSDGGWTVI QRRHDGSVDF NRPWEAYKAG FGDPHGEFWL GLEKVHSITG DRNSRLAVQL RDWDGNAELL QFSVHLGGED TAYSLQLTAP VAGQLGATTV PPSGLSVPFS TWDQDHDLRR DKNCAKSLSG GWWFGTCSHS NLNGQYFRSI PQQRQKLKKG IFWKTWRGRY YPLQATTMLI QPMAAE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ANGPTL4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ANGPTL4 Protein General Information | |
|---|---|
| Alternate Names | |
| ANGPTL4; NL2; pp1158; HARP; HFARP; TGQTL; UNQ171; ARP4; FIAF; PGAR | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ANGPTL4 |
| Entrez Gene ID | 51129 |
| Ensemble Gene ID | ENSG00000167772 |
| RefSeq Protein Accession(s) | NP_001034756.1 |
| RefSeq mRNA Accession(s) | NM_001039667.2, NM_139314.2 |
| UniProt ID(s) | Q9BY76 |
| UniGene ID(s) | Hs.9613 |
| HGNC ID(s) | HGNC:16039 |
| COSMIC ID Link(s) | ANGPTL4 |
| KEGG Gene ID(s) | hsa:51129 |
| PharmGKB ID(s) | PA24797 |
| General Description of Recombinant Human ANGPTL4 Protein. | |
| Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial Extracellular domain matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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