PDF DatasheetHuman CD146 / MCAM Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD146 / MCAM based upon sequence from: Human
Host: QP8689 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD146 / MCAM, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8689.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu50 – His646
Amino Acid Sequence: LSQSQGNLSH VDWFSVHKEK RTLIFRVRQG QGQSEPGEYE QRLSLQDRGA TLALTQVTPQ DERIFLCQGK RPRSQEYRIQ LRVYKAPEEP NIQVNPLGIP VNSKEPEEVA TCVGRNGYPI PQVIWYKNGR PLKEEKNRVH IQSSQTVESS GLYTLQSILK AQLVKEDKDA QFYCELNYRL PSGNHMKESR EVTVPVFYPT EKVWLEVEPV GMLKEGDRVE IRCLADGNPP PHFSISKQNP STREAEEETT NDNGVLVLEP ARKEHSGRYE CQGLDLDTMI SLLSEPQELL VNYVSDVRVS PAAPERQEGS SLTLTCEAES SQDLEFQWLR EETGQVLERG PVLQLHDLKR EAGGGYRCVA SVPSIPGLNR TQLVNVAIFG PPWMAFKERK VWVKENMVLN LSCEASGHPR PTISWNVNGT ASEQDQDPQR VLSTLNVLVT PELLETGVEC TASNDLGKNT SILFLELVNL TTLTPDSNTT TGLSTSTASP HTRANSTSTE RKLPEPESRG VVIVAVIVCI LVLAVLGAVL YFLYKKGKLP CRRSGKQEIT LPPSRKSELV VEVKSDKLPE EMGLLQGSSG DKRAPGDQGE KYIDLRH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CD146 / MCAM Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD146 / MCAM Protein General Information | |
|---|---|
| Alternate Names | |
| CD146; MCAM; s-endo; AV025631; CD149; s-gicerin; Muc18; CD146; 1-gicerin | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MCAM |
| Entrez Gene ID | 4162 |
| Ensemble Gene ID | ENSG00000076706 |
| RefSeq Protein Accession(s) | NP_006491.2 |
| RefSeq mRNA Accession(s) | NM_006500.2 |
| UniProt ID(s) | P43121 |
| UniGene ID(s) | Hs.599039 |
| HGNC ID(s) | HGNC:6934 |
| COSMIC ID Link(s) | MCAM |
| KEGG Gene ID(s) | hsa:4162 |
| PharmGKB ID(s) | PA30678 |
| General Description of Recombinant Human CD146 / MCAM Protein. | |
| Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elents of the vascular syst, thereby enhancing hatogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during bryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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