PDF DatasheetHuman Complement C3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Complement C3 based upon sequence from: Human
Host: QP8695 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Complement C3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8695.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Tyr26 – Lys225
Amino Acid Sequence: YSIITPNILR LESEETMVLE AHDAQGDVPV TVTVHDFPGK KLVLSSEKTV LTPATNHMGN VTFTIPANRE FKSEKGRNKF VTVQATFGTQ VVEKVVLVSL QSGYLFIQTD KTIYTPGSTV LYRIFTVNHK LLPVGRTVMV NIENPEGIPV KQDSLSSQNQ LGVLPLSWDI PELVNMGQWK IRAYYENSPQ QVFSTEFEVK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Complement C3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Complement C3 Protein General Information | |
|---|---|
| Alternate Names | |
| C3b; CPAMD1; AHUS5; C3a; ARMD9; ASP; HEL-S-62p | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | C3 |
| Entrez Gene ID | 718 |
| Ensemble Gene ID | ENSG00000125730 |
| RefSeq Protein Accession(s) | NP_000055.2 |
| RefSeq mRNA Accession(s) | NM_000064.3 |
| UniProt ID(s) | P01024 |
| UniGene ID(s) | Hs.529053 |
| HGNC ID(s) | HGNC:1318 |
| COSMIC ID Link(s) | C3 |
| KEGG Gene ID(s) | hsa:718 |
| PharmGKB ID(s) | PA25897 |
| General Description of Recombinant Human Complement C3 Protein. | |
| C3 plays a central role in the activation of the complent syst. Its processing by C3 convertase is the central reaction in both classical and alternative complent pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complent C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a choattractant for neutrophils . It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.C3-beta-c: Acts as a choattractant for neutrophils in chronic inflammation.Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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