PDF DatasheetHuman LCAT Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant LCAT based upon sequence from: Human
Host: QP8712 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) LCAT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8712.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Phe25 – Ser433
Amino Acid Sequence: FWLLNVLFPP HTTPKAELSN HTRPVILVPG CLGNQLEAKL DKPDVVNWMC YRKTEDFFTI WLDLNMFLPL GVDCWIDNTR VVYNRSSGLV SNAPGVQIRV PGFGKTYSVE YLDSSKLAGY LHTLVQNLVN NGYVRDETVR AAPYDWRLEP GQQEEYYRKL AGLVEEMHAA YGKPVFLIGH SLGCLHLLYF LLRQPQAWKD RFIDGFISLG APWGGSIKPM LVLASGDNQG IPIMSSIKLK EEQRITTTSP WMFPSRMAWP EDHVFISTPS FNYTGRDFQR FFADLHFEEG WYMWLQSRDL LAGLPAPGVE VYCLYGVGLP TPRTYIYDHG FPYTDPVGVL YEDGDDTVAT RSTELCGLWQ GRQPQPVHLL PLHGIQHLNM VFSNLTLEHI NAILLGAYRQ GPPASPTAS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human LCAT Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human LCAT Protein General Information | |
|---|---|
| Alternate Names | |
| LCAT | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LCAT |
| Entrez Gene ID | 3931 |
| Ensemble Gene ID | ENSG00000213398 |
| RefSeq Protein Accession(s) | NP_000220.1 |
| RefSeq mRNA Accession(s) | NM_000229.1 |
| UniProt ID(s) | P04180 |
| UniGene ID(s) | Hs.387239 |
| HGNC ID(s) | HGNC:6522 |
| COSMIC ID Link(s) | LCAT |
| KEGG Gene ID(s) | hsa:3931 |
| PharmGKB ID(s) | PA226 |
| General Description of Recombinant Human LCAT Protein. | |
| Central enzyme in the Extracellular domain metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for rodeling high-density lipoprotein particles into their spherical forms. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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