PDF DatasheetHuman Collagen alpha-1(IV) chain Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Collagen alpha-1(IV) chain based upon sequence from: Human
Host: QP8716 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Collagen alpha-1(IV) chain, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8716.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly30 – Pro167
Amino Acid Sequence: GCAGSGCGKC DCHGVKGQKG ERGLPGLQGV IGFPGMQGPE GPQGPPGQKG DTGEPGLPGT KGTRGPPGAS GYPGNPGLPG IPGQDGPPGP PGIPGCNGTK GERGPLGPPG LPGFAGNPGP PGLPGMKGDP GEILGHVP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Collagen alpha-1(IV) chain Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Collagen alpha-1(IV) chain Protein (30-167aa) General Information | |
|---|---|
| Alternate Names | |
| BSVD; RATOR | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COL4A1 |
| Entrez Gene ID | 1282 |
| Ensemble Gene ID | ENSG00000187498 |
| RefSeq Protein Accession(s) | NP_001290039.1 |
| RefSeq mRNA Accession(s) | NM_001303110.1, NM_001845.5 |
| UniProt ID(s) | P02462 |
| UniGene ID(s) | Hs.17441 |
| HGNC ID(s) | HGNC:2202 |
| COSMIC ID Link(s) | COL4A1 |
| KEGG Gene ID(s) | hsa:1282 |
| PharmGKB ID(s) | PA26717 |
| General Description of Recombinant Human Collagen alpha-1(IV) chain Protein (30-167aa). | |
| Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a ‘chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen.Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.