PDF DatasheetHuman P63 / TP63 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant P63 / TP63 based upon sequence from: Human
Host: QP8724 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) P63 / TP63, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8724.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Glu680
Amino Acid Sequence: MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND FNFDMDARRN KQQRIKEEGE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human P63 / TP63 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human P63 / TP63 Protein General Information | |
|---|---|
| Alternate Names | |
| P63; TP63; B(p51A); LMS; AIS; OFC8; EEC3; SHFM4; TP53CP; p73L; B(p51B); KET; TP53L; p40; p51; p63; p73H; p53CP; RHS; TP73L; NBP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TP63 |
| Entrez Gene ID | 8626 |
| Ensemble Gene ID | ENSG00000073282 |
| RefSeq Protein Accession(s) | NP_001108450.1 |
| RefSeq mRNA Accession(s) | NM_001114978.1, NM_001114979.1, NM_001114980.1, NM_001114981.1, NM_001114982.1, NM_001329144.1, NM_001329145.1, NM_001329146.1, NM_001329148.1, NM_003722.4, XM_017007387.1 |
| UniProt ID(s) | Q9H3D4 |
| UniGene ID(s) | Hs.137569 |
| HGNC ID(s) | HGNC:15979 |
| COSMIC ID Link(s) | TP63 |
| KEGG Gene ID(s) | hsa:8626 |
| PharmGKB ID(s) | PA162406776 |
| General Description of Recombinant Human P63 / TP63 Protein. | |
| Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial st cell compartments and regulate the initiation of epithelial stratification from the undifferentiated bryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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