PDF DatasheetHuman Glutamate carboxypeptidase 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Glutamate carboxypeptidase 2 based upon sequence from: Human
Host: QP8726 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glutamate carboxypeptidase 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8726.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu48 – Ala750
Amino Acid Sequence: EATNITPKHN MKAFLDELKA ENIKKFLYNF TQIPHLAGTE QNFQLAKQIQ SQWKEFGLDS VELAHYDVLL SYPNKTHPNY ISIINEDGNE IFNTSLFEPP PPGYENVSDI VPPFSAFSPQ GMPEGDLVYV NYARTEDFFK LERDMKINCS GKIVIARYGK VFRGNKVKNA QLAGAKGVIL YSDPADYFAP GVKSYPDGWN LPGGGVQRGN ILNLNGAGDP LTPGYPANEY AYRRGIAEAV GLPSIPVHPI GYYDAQKLLE KMGGSAPPDS SWRGSLKVPY NVGPGFTGNF STQKVKMHIH STNEVTRIYN VIGTLRGAVE PDRYVILGGH RDSWVFGGID PQSGAAVVHE IVRSFGTLKK EGWRPRRTIL FASWDAEEFG LLGSTEWAEE NSRLLQERGV AYINADSSIE GNYTLRVDCT PLMYSLVHNL TKELKSPDEG FEGKSLYESW TKKSPSPEFS GMPRISKLGS GNDFEVFFQR LGIASGRARY TKNWETNKFS GYPLYHSVYE TYELVEKFYD PMFKYHLTVA QVRGGMVFEL ANSIVLPFDC RDYAVVLRKY ADKIYSISMK HPQEMKTYSV SFDSLFSAVK NFTEIASKFS ERLQDFDKSN PIVLRMMNDQ LMFLERAFID PLGLPDRPFY RHVIYAPSSH NKYAGESFPG IYDALFDIES KVDPSKAWGE VKRQIYVAAF TVQAAAETLS EVA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Glutamate carboxypeptidase 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Glutamate carboxypeptidase 2 Protein General Information | |
|---|---|
| Alternate Names | |
| FOLH; NAALAD1; NAALAdase; PSMA; GCPII; FGCP; GCP2; PSM; mGCP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FOLH |
| Entrez Gene ID | 2346 |
| Ensemble Gene ID | ENSG00000086205 |
| RefSeq Protein Accession(s) | NP_001014986.1 |
| RefSeq mRNA Accession(s) | NM_001014986.1, NM_001193471.1, NM_001193472.1, NM_001193473.1, NM_004476.1, XM_017017434.1, XM_017017435.1, XM_017017436.1, XM_017017437.1, XM_017017442.1, XM_017017443.1, XM_017017444.1, XM_017017445.1, XM_017017446.1, XM_017017447.1, XM_017017448.1 |
| UniProt ID(s) | Q04609 |
| UniGene ID(s) | Hs.551896 |
| HGNC ID(s) | HGNC:3788 |
| KEGG Gene ID(s) | hsa:2346 |
| PharmGKB ID(s) | PA28205 |
| General Description of Recombinant Human Glutamate carboxypeptidase 2 Protein. | |
| Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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