PDF DatasheetHuman MGMT Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MGMT based upon sequence from: Human
Host: QP8730 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MGMT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8730.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn207
Amino Acid Sequence: MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human MGMT Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human MGMT Protein General Information | |
|---|---|
| Alternate Names | |
| ; Methylated-DNA–protein-cysteine methyltransfera | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MGMT |
| Entrez Gene ID | 4255 |
| Ensemble Gene ID | ENSG00000170430 |
| RefSeq Protein Accession(s) | XP_005252739.1 |
| RefSeq mRNA Accession(s) | XM_005252682.2 |
| UniProt ID(s) | P16455 |
| UniGene ID(s) | Hs.501522 |
| HGNC ID(s) | HGNC:7059 |
| COSMIC ID Link(s) | MGMT |
| General Description of Recombinant Human MGMT Protein. | |
| Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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