PDF DatasheetHuman Collagen alpha-2(IV) chain Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Collagen alpha-2(IV) chain based upon sequence from: Human
Host: QP8734 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Collagen alpha-2(IV) chain, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8734.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val1493 – Leu1712
Amino Acid Sequence: VKHSQTDQEP MCPVGMNKLW SGYSLLYFEG QEKAHNQDLG LAGSCLARFS TMPFLYCNPG DVCYYASRND KSYWLSTTAP LPMMPVAEDE IKPYISRCSV CEAPAIAIAV HSQDVSIPHC PAGWRSLWIG YSFLMHTAAG DEGGGQSLVS PGSCLEDFRA TPFIECNGGR GTCHYYANKY SFWLTTIPEQ SFQGSPSADT LKAGLIRTHI SRCQVCMKNL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Collagen alpha-2(IV) chain Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Collagen alpha-2(IV) chain Protein General Information | |
|---|---|
| Alternate Names | |
| POREN2; ICH | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COL4A2 |
| Entrez Gene ID | 1284 |
| Ensemble Gene ID | ENSG00000134871 |
| RefSeq Protein Accession(s) | NP_001837.2 |
| RefSeq mRNA Accession(s) | NM_001846.3 |
| UniProt ID(s) | P08572 |
| UniGene ID(s) | Hs.508716 |
| HGNC ID(s) | HGNC:2203 |
| COSMIC ID Link(s) | COL4A2 |
| KEGG Gene ID(s) | hsa:1284 |
| PharmGKB ID(s) | PA26718 |
| General Description of Recombinant Human Collagen alpha-2(IV) chain Protein. | |
| Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a ‘chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen.Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial mbrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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