PDF DatasheetHuman B7-H4 / B7S1 / B7x Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant B7-H4 / B7S1 / B7x based upon sequence from: Human
Host: QP8751 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) B7-H4 / B7S1 / B7x, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8751.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ile26 – Ala258
Amino Acid Sequence: IIGFGISGRH SITVTTVASA GNIGEDGILS CTFEPDIKLS DIVIQWLKEG VLGLVHEFKE GKDELSEQDE MFRGRTAVFA DQVIVGNASL RLKNVQLTDA GTYKCYIITS KGKGNANLEY KTGAFSMPEV NVDYNASSET LRCEAPRWFP QPTVVWASQV DQGANFSEVS NTSFELNSEN VTMKVVSVLY NVTINNTYSC MIENDIAKAT GDIKVTESEI KRRSHLQLLN SKA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human B7-H4 / B7S1 / B7x Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human B7-H4 / B7S1 / B7x Protein General Information | |
|---|---|
| Alternate Names | |
| B7-H4; B7S1; B7x; B7X; PRO1291; B7-H4; B7S1; VCTN1; B7H4; B7h.5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | VTCN1 |
| Entrez Gene ID | 79679 |
| Ensemble Gene ID | ENSG00000134258 |
| RefSeq Protein Accession(s) | NP_001240778.1 |
| RefSeq mRNA Accession(s) | NM_001253849.1, NM_001253850.1, NM_024626.3 |
| UniProt ID(s) | Q7Z7D3 |
| UniGene ID(s) | Hs.546434 |
| HGNC ID(s) | HGNC:28873 |
| COSMIC ID Link(s) | VTCN1 |
| KEGG Gene ID(s) | hsa:79679 |
| PharmGKB ID(s) | PA142670611 |
| General Description of Recombinant Human B7-H4 / B7S1 / B7x Protein. | |
| Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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