PDF DatasheetHuman E3 ubiquitin-protein ligase MIB1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase MIB1 based upon sequence from: Human
Host: QP8760 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase MIB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8760.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Arg5 – Gln332
Amino Acid Sequence: RNNRVMVEGV GARVVRGPDW KWGKQDGGEG HVGTVRSFES PEEVVVVWDN GTAANYRCSG AYDLRILDSA PTGIKHDGTM CDTCRQQPII GIRWKCAECT NYDLCTVCYH GDKHHLRHRF YRITTPGSER VLLESRRKSK KITARGIFAG ARVVRGVDWQ WEDQDGGNGR RGKVTEIQDW SASSPHSAAY VLWDNGAKNL YRVGFEGMSD LKCVQDAKGG SFYRDHCPVL GEQNGNRNPG GLQIGDLVNI DLDLEIVQSL QHGHGGWTDG MFETLTTTGT VCGIDEDHDI VVQYPSGNRW TFNPAVLTKA NIVRSGDAAQ GAEGGTSQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human E3 ubiquitin-protein ligase MIB1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human E3 ubiquitin-protein ligase MIB1 Protein General Information | |
|---|---|
| Alternate Names | |
| DIP1; ZZANK2; DIP-1; ZZZ6; MIB; LVNC7 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MIB1 |
| Entrez Gene ID | 57534 |
| Ensemble Gene ID | ENSG00000101752 |
| RefSeq Protein Accession(s) | NP_065825.1 |
| RefSeq mRNA Accession(s) | NM_020774.3 |
| UniProt ID(s) | Q86YT6 |
| UniGene ID(s) | Hs.140903 |
| HGNC ID(s) | HGNC:21086 |
| COSMIC ID Link(s) | MIB1 |
| KEGG Gene ID(s) | hsa:57534 |
| PharmGKB ID(s) | PA134862722 |
| General Description of Recombinant Human E3 ubiquitin-protein ligase MIB1 Protein. | |
| E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates ‘Lys-63’-linked polyubiquitination of TBK1, which probably participates in kinase activation.1 Publication | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.