![SDS-PAGE separation of QP8781 followed by commassie total protein stain results in a primary band consistent with reported data for Carbonyl reductase [NADPH] 1. These data demonstrate Greater than 90% as determined by SDS-PAGE.](https://cdn-enquirebio.pressidium.com/wp-content/uploads/2018/01/QP8781-Human-Carbonyl-reductase-NADPH-1-1.jpg "SDS-PAGE separation of QP8781 followed by commassie total protein stain results in a primary band consistent with reported data for Carbonyl reductase [NADPH] 1. These data demonstrate Greater than 90% as determined by SDS-PAGE.")
PDF DatasheetHuman Carbonyl reductase [NADPH] 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Carbonyl reductase [NADPH] 1 based upon sequence from: Human
Host: QP8781 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Carbonyl reductase [NADPH] 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8781.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Trp277
Amino Acid Sequence: SSGIHVALVT GGNKGIGLAI VRDLCRLFSG DVVLTARDVT RGQAAVQQLQ AEGLSPRFHQ LDIDDLQSIR ALRDFLRKEY GGLDVLVNNA GIAFKVADPT PFHIQAEVTM KTNFFGTRDV CTELLPLIKP QGRVVNVSSI MSVRALKSCS PELQQKFRSE TITEEELVGL MNKFVEDTKK GVHQKEGWPS SAYGVTKIGV TVLSRIHARK LSEQRKGDKI LLNACCPGWV RTDMAGPKAT KSPEEGAETP VYLALLPPDA EGPHGQFVSE KRVEQW
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Carbonyl reductase [NADPH] 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Carbonyl reductase Protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| SDR21C1; hCBR1; CBR | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CBR1 |
| Entrez Gene ID | 873 |
| Ensemble Gene ID | ENSG00000159228 |
| RefSeq Protein Accession(s) | NP_001273718.1 |
| RefSeq mRNA Accession(s) | NM_001286789.1, NM_001757.3 |
| UniProt ID(s) | P16152 |
| UniGene ID(s) | Hs.88778 |
| HGNC ID(s) | HGNC:1548 |
| COSMIC ID Link(s) | CBR1 |
| KEGG Gene ID(s) | hsa:873 |
| PharmGKB ID(s) | PA26121 |
| General Description of Recombinant Human Carbonyl reductase Protein 1 Protein. | |
| NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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