PDF DatasheetHuman AGER / RAGE Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant AGER / RAGE based upon sequence from: Human
Host: QP8786 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) AGER / RAGE, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8786.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ala23 – Ala342
Amino Acid Sequence: AQNITARIGE PLVLKCKGAP KKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human AGER / RAGE Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human AGER / RAGE Protein General Information | |
|---|---|
| Alternate Names | |
| AGER; RAGE; SCARJ1; RAGE | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AGER |
| Entrez Gene ID | 177 |
| Ensemble Gene ID | ENSG00000204305 |
| RefSeq Protein Accession(s) | NP_001127.1 |
| RefSeq mRNA Accession(s) | NM_001136.4, NM_001206929.1, NM_001206932.1, NM_001206934.1, NM_001206936.1, NM_001206940.1, NM_001206954.1, NM_001206966.1, NM_172197.2 |
| UniProt ID(s) | Q15109 |
| UniGene ID(s) | Hs.534342 |
| HGNC ID(s) | HGNC:320 |
| COSMIC ID Link(s) | AGER |
| KEGG Gene ID(s) | hsa:177 |
| PharmGKB ID(s) | PA24617 |
| General Description of Recombinant Human AGER / RAGE Protein. | |
| Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell mbrane from the Extracellular domain to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport syst delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.4 Publications | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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