PDF DatasheetHuman Laminin subunit beta-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Laminin subunit beta-1 based upon sequence from: Human
Host: QP8789 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Laminin subunit beta-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8789.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1533 – Tyr1782
Amino Acid Sequence: MPSTPQQLQN LTEDIRERVE SLSQVEVILQ HSAADIARAE MLLEEAKRAS KSATDVKVTA DMVKEALEEA EKAQVAAEKA IKQADEDIQG TQNLLTSIES ETAASEETLF NASQRISELE RNVEELKRKA AQNSGEAEYI EKVVYTVKQS AEDVKKTLDG ELDEKYKKVE NLIAKKTEES ADARRKAEML QNEAKTLLAQ ANSKLQLLKD LERKYEDNQR YLEDKAQELA RLEGEVRSLL KDISQKVAVY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Laminin subunit beta-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Laminin subunit beta-1 Protein General Information | |
|---|---|
| Alternate Names | |
| CLM; LIS5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LAMB1 |
| Entrez Gene ID | 3912 |
| Ensemble Gene ID | ENSG00000091136 |
| RefSeq Protein Accession(s) | NP_002282.2 |
| RefSeq mRNA Accession(s) | NM_002291.2 |
| UniProt ID(s) | P07942 |
| UniGene ID(s) | Hs.650585 |
| HGNC ID(s) | HGNC:6486 |
| COSMIC ID Link(s) | LAMB1 |
| KEGG Gene ID(s) | hsa:3912 |
| PharmGKB ID(s) | PA30275 |
| General Description of Recombinant Human Laminin subunit beta-1 Protein. | |
| Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during bryonic development by interacting with other Extracellular domain matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basent mbrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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