PDF DatasheetChicken Focal adhesion kinase 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Focal adhesion kinase 1 based upon sequence from: Chicken
Host: QP8800 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Gallus gallus (Chicken) Focal adhesion kinase 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8800.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu376 – Glu683
Amino Acid Sequence: LANNEKQGVR SHTVSVSETD DYAEIIDEED TYTMPSTRDY EIQRERIELG RCIGEGQFGD VHQGIYMSPE NPAMAVAIKT CKNCTSDSVR EKFLQEALTM RQFDHPHIVK LIGVITENPV WIIMELCTLG ELRSFLQVRK FSLDLASLIL YAYQLSTALA YLESKRFVHR DIAARNVLVS ATDCVKLGDF GLSRYMEDST YYKASKGKLP IKWMAPESIN FRRFTSASDV WMFGVCMWEI LMHGVKPFQG VKNNDVIGRI ENGERLPMPP NCPPTLYSLM TKCWAYDPSR RPRFTELKAQ LSTILEEE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Chicken Focal adhesion kinase 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Chicken Focal adhesion kinase 1 Protein General Information | |
|---|---|
| Alternate Names | |
| FRNK; FAK; p125FAK | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTK2 |
| Entrez Gene ID | 396416 |
| Ensemble Gene ID | ENSGALG00000031741 |
| RefSeq Protein Accession(s) | NP_990766.1 |
| RefSeq mRNA Accession(s) | NM_205435.1 |
| UniProt ID(s) | Q00944 |
| UniGene ID(s) | Gga.15614 |
| KEGG Gene ID(s) | gga:396416 |
| General Description of Recombinant Chicken Focal adhesion kinase 1 Protein. | |
| Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassbly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early bryonic development, bryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous syst. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family mbers upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family mbers mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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