PDF DatasheetHuman Titin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Titin based upon sequence from: Human
Host: QP8823 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Titin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8823.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val5398 – Phe5604
Amino Acid Sequence: VGSSICSARV TLREPPSFIK KIESTSSLRG GTAAFQATLK GSLPITVTWL KDSDEITEDD NIRMTFENNV ASLYLSGIEV KHDGKYVCQA KNDAGIQRCS ALLSVKEPAT ITEEAVSIDV TQGDPATLQV KFSGTKEITA KWFKDGQELT LGSKYKISVT DTVSILKIIS TEKKDSGEYT FEVQNDVGRS SCKARINVLD LIIPPSF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Titin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Titin Protein General Information | |
|---|---|
| Alternate Names | |
| MYLK5; CMH9; CMPD4; CMD1G; TMD; EOMFC; LGMD2J; HMERF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TTN |
| Entrez Gene ID | 7273 |
| Ensemble Gene ID | ENSG00000155657 |
| RefSeq Protein Accession(s) | NP_001243779.1 |
| RefSeq mRNA Accession(s) | NM_001256850.1, NM_003319.4, NM_133378.4, NM_133379.4, NM_133432.3 |
| UniProt ID(s) | Q8WZ42 |
| UniGene ID(s) | Hs.134602 |
| HGNC ID(s) | HGNC:12403 |
| KEGG Gene ID(s) | hsa:7273 |
| PharmGKB ID(s) | PA37067 |
| General Description of Recombinant Human Titin Protein. | |
| Key component in the assbly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, ses to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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