PDF DatasheetHuman Smad2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Smad2 based upon sequence from: Human
Host: QP8839 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Smad2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8839.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Ser467
Amino Acid Sequence: SSILPFTPPV VKRLLGWKKS AGGSGGAGGG EQNGQEEKWC EKAVKSLVKK LKKTGRLDEL EKAITTQNCN TKCVTIPSTC SEIWGLSTPN TIDQWDTTGL YSFSEQTRSL DGRLQVSHRK GLPHVIYCRL WRWPDLHSHH ELKAIENCEY AFNLKKDEVC VNPYHYQRVE TPVLPPVLVP RHTEILTELP PLDDYTHSIP ENTNFPAGIE PQSNYIPETP PPGYISEDGE TSDQQLNQSM DTGSPAELSP TTLSPVNHSL DLQPVTYSEP AFWCSIAYYE LNQRVGETFH ASQPSLTVDG FTDPSNSERF CLGLLSNVNR NATVEMTRRH IGRGVRLYYI GGEVFAECLS DSAIFVQSPN CNQRYGWHPA TVCKIPPGCN LKIFNNQEFA ALLAQSVNQG FEAVYQLTRM CTIRMSFVKG WGAEYRRQTV TSTPCWIELH LNGPLQWLDK VLTQMGSPSV RCSSMS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Smad2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Smad2 Protein General Information | |
|---|---|
| Alternate Names | |
| Smad2; Madh2; Madr2; Smad-2; 7120426M23Rik; mMad2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SMAD2 |
| Entrez Gene ID | 4087 |
| Ensemble Gene ID | ENSG00000175387 |
| RefSeq Protein Accession(s) | NP_001003652.1 |
| RefSeq mRNA Accession(s) | NM_001003652.3, NM_005901.5, XM_005258259.3, XM_006722451.3, XM_017025745.1, XM_017025746.1 |
| UniProt ID(s) | Q15796 |
| UniGene ID(s) | Hs.12253 |
| HGNC ID(s) | HGNC:6768 |
| COSMIC ID Link(s) | SMAD2 |
| KEGG Gene ID(s) | hsa:4087 |
| PharmGKB ID(s) | PA134959722 |
| General Description of Recombinant Human Smad2 Protein. | |
| Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE elent in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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