PDF DatasheetHuman NR2C2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NR2C2 based upon sequence from: Human
Host: QP8855 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NR2C2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8855.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser3 – Thr592
Amino Acid Sequence: SPSPRIQIIS TDSAVASPQR IQIVTDQQTG QKIQIVTAVD ASGSSKQQFI LTSPDGAGTG KVILASPETS SAKQLIFTTS DNLVPGRIQI VTDSASVERL LGKADVQRPQ VVEYCVVCGD KASGRHYGAV SCEGCKGFFK RSVRKNLTYS CRSSQDCIIN KHHRNRCQFC RLKKCLEMGM KMESVQSERK PFDVQREKPS NCAASTEKIY IRKDLRSPLI ATPTFVADKD GARQTGLLDP GMLVNIQQPL IREDGTVLLA ADSKAETSQG ALGTLANVVT SLANLSESLN NGDASEMQPE DQSASEITRA FDTLAKALNT TDSASPPSLA DGIDASGGGS IHVISRDQST PIIEVEGPLL SDTHVTFKLT MPSPMPEYLN VHYICESASR LLFLSMHWAR SIPAFQALGQ DCNTSLVRAC WNELFTLGLA QCAQVMSLST ILAAIVNHLQ NSIQEDKLSG DRIKQVMEHI WKLQEFCNSM AKLDIDGYEY AYLKAIVLFS PDHPGLTGTS QIEKFQEKAQ MELQDYVQKT YSEDTYRLAR ILVRLPALRL MSSNITEELF FTGLIGNVSI DSIIPYILKM ETAEYNGQIT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NR2C2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NR2C2 Protein General Information | |
|---|---|
| Alternate Names | |
| mKIAA4145; TAK1; Tr4; Nuclear receptor subfamily 2 group C member | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NR2C2 |
| Entrez Gene ID | 22026 |
| Ensemble Gene ID | ENSMUSG00000005893 |
| RefSeq Protein Accession(s) | NP_001334271.1 |
| RefSeq mRNA Accession(s) | NM_001347342.1, NM_011630.3, XM_006505904.3, XM_006505905.3, XM_006505906.3 |
| UniProt ID(s) | P49117 |
| UniGene ID(s) | Mm.442385 |
| COSMIC ID Link(s) | NR2C2 |
| KEGG Gene ID(s) | mmu:22026 |
| General Description of Recombinant Human NR2C2 Protein. | |
| Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation . Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses bryonic and fetal globin transcription including that of GATA1. Binds to hormone response elents (HREs) consisting of two 5′-AGGTCA-3′ half site direct repeat consensus sequences. Plays a fundamental role in early bryonic development and bryonic st cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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