PDF DatasheetRat Haptoglobin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Haptoglobin based upon sequence from: Rat
Host: QP8887 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Haptoglobin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8887.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val19 – Lys346
Amino Acid Sequence: VELGNDATDI EDDSCPKPPE IANGYVEHLV RYRCRQFYKL QTEGDGIYTL NSEKQWVNPA AGDKLPKCEA VCGKPKHPVD QVQRIIGGSM DAKGSFPWQA KMISRHGLTT GATLISDQWL LTTAQNLFLN HSENATAKDI APTLTLYVGK NQLVEIEKVV LHPERSVVDI GLIKLKQKVL VTEKVMPICL PSKDYVAPGR MGYVSGWGRN VNFRFTERLK YVMLPVADQE KCELHYEKST VPEKKGAVSP VGVQPILNKH TFCAGLTKYE EDTCYGDAGS AFAVHDTEED TWYAAGILSF DKSCAVAEYG VYVRATDLKD WVQETMAK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rat Haptoglobin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Haptoglobin Protein General Information | |
|---|---|
| Alternate Names | |
| Ba1-647 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HP |
| Entrez Gene ID | 24464 |
| RefSeq Protein Accession(s) | NP_036714.2 |
| RefSeq mRNA Accession(s) | NM_012582.2 |
| UniProt ID(s) | P06866 |
| UniGene ID(s) | Rn.10950 |
| COSMIC ID Link(s) | HP |
| KEGG Gene ID(s) | rno:24464 |
| General Description of Recombinant Rat Haptoglobin Protein. | |
| As a result of holysis, hoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hoglobin to allow hepatic recycling of he iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway .Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassbly, and controlling the equilibrium between tolerance and immunity to non-self antigens. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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