PDF DatasheetDISCONTINUED:
Human Proto-oncogene c-Rel Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Proto-oncogene c-Rel based upon sequence from: Human
Host: QP8904 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Proto-oncogene c-Rel, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8904.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser3 – Phe616
Amino Acid Sequence: SGAYNPYIEI IEQPRQRGMR FRYKCEGRSA GSIPGEHSTD NNRTYPSIQI MNYYGKGKVR ITLVTKNDPY KPHPHDLVGK DCRDGYYEAE FGQERRPLFF QNLGIRCVKK KEVKEAIITR IKAGINPFNV PEKQLNDIED CDLNVVRLCF QVFLPDEHGN LTTALPPVVS NPIYDNRAPN TAELRICRVN KNCGSVRGGD EIFLLCDKVQ KDDIEVRFVL NDWEAKGIFS QADVHRQVAI VFKTPPYCKA ITEPVTVKMQ LRRPSDQEVS ESMDFRYLPD EKDTYGNKAK KQKTTLLFQK LCQDHVETGF RHVDQDGLEL LTSGDPPTLA SQSAGITVNF PERPRPGLLG SIGEGRYFKK EPNLFSHDAV VREMPTGVSS QAESYYPSPG PISSGLSHHA SMAPLPSSSW SSVAHPTPRS GNTNPLSSFS TRTLPSNSQG IPPFLRIPVG NDLNASNACI YNNADDIVGM EASSMPSADL YGISDPNMLS NCSVNMMTTS SDSMGETDNP RLLSMNLENP SCNSVLDPRD LRQLHQMSSS SMSAGANSNT TVFVSQSDAF EGSDFSCADN SMINESGPSN STNPNSHGFV QDSQYSGIGS MQNEQLSDSF PYEF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Proto-oncogene c-Rel Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Proto-oncogene c-Rel Protein General Information | |
|---|---|
| Alternate Names | |
| C-Rel | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | REL |
| Entrez Gene ID | 5966 |
| Ensemble Gene ID | ENSG00000162924 |
| RefSeq Protein Accession(s) | NP_001278675.1 |
| RefSeq mRNA Accession(s) | NM_001291746.1, NM_002908.3 |
| UniProt ID(s) | Q04864 |
| UniGene ID(s) | Hs.631886 |
| HGNC ID(s) | HGNC:9954 |
| COSMIC ID Link(s) | REL |
| KEGG Gene ID(s) | hsa:5966 |
| PharmGKB ID(s) | PA34321 |
| General Description of Recombinant Human Proto-oncogene c-Rel Protein. | |
| Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with mbers of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.