PDF DatasheetHuman Histone acetyltransferase KAT5 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Histone acetyltransferase KAT5 based upon sequence from: Human
Host: QP8905 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Histone acetyltransferase KAT5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8905.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu3 – Trp513
Amino Acid Sequence: EVGEIIEGCR LPVLRRNQDN EDEWPLAEIL SVKDISGRKL FYVHYIDFNK RLDEWVTHER LDLKKIQFPK KEAKTPTKNG LPGSRPGSPE REVPASAQAS GKTLPIPVQI TLRFNLPKER EAIPGGEPDQ PLSSSSCLQP NHRSTKRKVE VVSPATPVPS ETAPASVFPQ NGAARRAVAA QPGRKRKSNC LGTDEDSQDS SDGIPSAPRM TGSLVSDRSH DDIVTRMKNI ECIELGRHRL KPWYFSPYPQ ELTTLPVLYL CEFCLKYGRS LKCLQRHLTK CDLRHPPGNE IYRKGTISFF EIDGRKNKSY SQNLCLLAKC FLDHKTLYYD TDPFLFYVMT EYDCKGFHIV GYFSKEKEST EDYNVACILT LPPYQRRGYG KLLIEFSYEL SKVEGKTGTP EKPLSDLGLL SYRSYWSQTI LEILMGLKSE SGERPQITIN EISEITSIKK EDVISTLQYL NLINYYKGQY ILTLSEDIVD GHERAMLKRL LRIDSKCLHF TPKDWSKRGK W
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Histone acetyltransferase KAT5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Histone acetyltransferase KAT5 Protein General Information | |
|---|---|
| Alternate Names | |
| HTATIP; cPLA2; TIP; ESA1; HTATIP1; PLIP; TIP60; ZC2HC5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KAT5 |
| Entrez Gene ID | 10524 |
| Ensemble Gene ID | ENSG00000172977 |
| RefSeq Protein Accession(s) | NP_001193762.1 |
| RefSeq mRNA Accession(s) | NM_001206833.1, NM_006388.3, NM_182709.2, NM_182710.2 |
| UniProt ID(s) | Q92993 |
| UniGene ID(s) | Hs.397010 |
| HGNC ID(s) | HGNC:5275 |
| COSMIC ID Link(s) | KAT5 |
| KEGG Gene ID(s) | hsa:10524 |
| PharmGKB ID(s) | PA162392746 |
| General Description of Recombinant Human Histone acetyltransferase KAT5 Protein. | |
| Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the roval of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.