PDF DatasheetHuman HDAC4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HDAC4 based upon sequence from: Human
Host: QP8906 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HDAC4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8906.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – His227
Amino Acid Sequence: MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA MKHQQELLEH QRKLERHRQE QELEKQHREQ KLQQLKNKEK GKESAVASTE VKMKLQEFVL NKKKALAHRN LNHCISSDPR YWYGKTQHSS LDQSSPPQSG VSTSYNH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human HDAC4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HDAC4 Protein General Information | |
|---|---|
| Alternate Names | |
| HDAC4; HA6116; HDAC-4; AHO3; HD4; BDMR; HDAC-A; HDACA | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HDAC4 |
| Entrez Gene ID | 9759 |
| Ensemble Gene ID | ENSG00000068024 |
| RefSeq Protein Accession(s) | NP_006028.2 |
| RefSeq mRNA Accession(s) | NM_006037.3 |
| UniProt ID(s) | P56524 |
| UniGene ID(s) | Hs.20516 |
| HGNC ID(s) | HGNC:14063 |
| COSMIC ID Link(s) | HDAC4 |
| KEGG Gene ID(s) | hsa:9759 |
| PharmGKB ID(s) | PA29229 |
| General Description of Recombinant Human HDAC4 Protein. | |
| Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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