PDF DatasheetHuman Histone deacetylase 7 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Histone deacetylase 7 based upon sequence from: Human
Host: QP8907 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Histone deacetylase 7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8907.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val645 – Ala915
Amino Acid Sequence: VTDLAFKVAS RELKNGFAVV RPPGHHADHS TAMGFCFFNS VAIACRQLQQ QSKASKILIV DWDVHHGNGT QQTFYQDPSV LYISLHRHDD GNFFPGSGAV DEVGAGSGEG FNVNVAWAGG LDPPMGDPEY LAAFRIVVMP IAREFSPDLV LVSAGFDAAE GHPAPLGGYH VSAKCFGYMT QQLMNLAGGA VVLALEGGHD LTAICDASEA CVAALLGNRV DPLSEEGWKQ KPNLNAIRSL EAVIRVHSKY WGCMQRLASC PDSWVPRVPG A
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Histone deacetylase 7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Histone deacetylase 7 Protein (645-915aa) General Information | |
|---|---|
| Alternate Names | |
| HD7; HDAC7A; HD7A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HDAC7 |
| Entrez Gene ID | 51564 |
| Ensemble Gene ID | ENSG00000061273 |
| RefSeq Protein Accession(s) | NP_001091886.1 |
| RefSeq mRNA Accession(s) | NM_001098416.3, NM_001308090.1, NM_015401.4, XM_011538481.1, XM_011538482.1 |
| UniProt ID(s) | Q8WUI4 |
| UniGene ID(s) | Hs.200063 |
| HGNC ID(s) | HGNC:14067 |
| COSMIC ID Link(s) | HDAC7 |
| KEGG Gene ID(s) | hsa:51564 |
| PharmGKB ID(s) | PA162390579 |
| General Description of Recombinant Human Histone deacetylase 7 Protein (645-915aa). | |
| Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors . May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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