PDF DatasheetHuman Gap junction alpha-1 protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Gap junction alpha-1 protein based upon sequence from: Human
Host: QP8916 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Gap junction alpha-1 protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8916.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Phe233 – Ile382
Amino Acid Sequence: FKGVKDRVKG KSDPYHATSG ALSPAKDCGS QKYAYFNGCS SPTAPLSPMS PPGYKLVTGD RNNSSCRNYN KQASEQNWAN YSAEQNRMGQ AGSTISNSHA QPFDFPDDNQ NSKKLAAGHE LQPLAIVDQR PSSRASSRAS SRPRPDDLEI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Gap junction alpha-1 protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Gap junction alpha-1 protein Protein General Information | |
|---|---|
| Alternate Names | |
| AVSD3; EKVP; PPKCA; GJAL; CX43; ODDD; HSS; CMDR; HLHS1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GJA1 |
| UniProt ID(s) | P17302 |
| COSMIC ID Link(s) | GJA1 |
| General Description of Recombinant Human Gap junction alpha-1 protein Protein. | |
| Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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