PDF DatasheetInfluenza Influenza A H7N9 (A / Shanghai / 02 / 2013) Hemagglutinin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Influenza A H7N9 (A / Shanghai / 02 / 2013) Hemagglutinin based upon sequence from: Influenza
Host: QP8948 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Influenza A virus (A/chicken/Jiangsu/1021/2013(H7N9)) Influenza A H7N9 (A/Shanghai/02/2013) Hemagglutinin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8948.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asp19 – Val524
Amino Acid Sequence: DKICLGHHAV SNGTKVNTLT ERGVEVVNAT ETVERTNIPR ICSKGKRTVD LGQCGLLGTI TGPPQCDQFL EFSADLIIER REGSDVCYPG KFVNEEALRQ ILRESGGIDK EAMGFTYSGI RTNGATSACR RSGSSFYAEM KWLLSNTDNA AFPQMTKSYK NTRKSPALIV WGIHHSVSTA EQTKLYGSGN KLVTVGSSNY QQSFVPSPGA RPQVNGLSGR IDFHWLMLNP NDTVTFSFNG AFIAPDRASF LRGKSMGIQS GVQVDANCEG DCYHSGGTII SNLPFQNIDS RAVGKCPRYV KQRSLLLATG MKNVPEIPKG RGLFGAIAGF IENGWEGLID GWYGFRHQNA QGEGTAADYK STQSAIDQIT GKLNRLIEKT NQQFELIDNE FNEVEKQIGN VINWTRDSIT EVWSYNAELL VAMENQHTID LADSEMDKLY ERVKRQLREN AEEDGTGCFE IFHKCDDDCM ASIRNNTYDH SKYREEAMQN RIQIDPVKLS SGYKDV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Influenza Influenza A H7N9 (A / Shanghai / 02 / 2013) Hemagglutinin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Influenza Influenza A H7N9 (A / Shanghai / 02 / 2013) Hemagglutinin Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HA |
| Entrez Gene ID | 23104227 |
| RefSeq Protein Accession(s) | YP_009118475.1 |
| RefSeq mRNA Accession(s) | NC_026425.1 |
| UniProt ID(s) | R4NN21 |
| KEGG Gene ID(s) | vg:23104227 |
| General Description of Recombinant Influenza Influenza A H7N9 (A / Shanghai / 02 / 2013) Hemagglutinin Protein. | |
| Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the mbrane of the endocytosed virus particle with the endosomal mbrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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