PDF DatasheetRat A2M / CPAMD5 / Alpha-2-macroglobulin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant A2M / CPAMD5 / Alpha-2-macroglobulin based upon sequence from: Rat
Host: QP8951 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) A2M / CPAMD5 / Alpha-2-macroglobulin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8951.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu620 – Ala750
Amino Acid Sequence: LIYDLLPVKD LTGFPQGADQ REEDTNGCVK QNDTYINGIL YSPVQNTNEE DMYGFLKDMG LKVFTNSNIR KPKVCERLRD NKGIPAAYHL VSQSHMDAFL ESSESPTETR RSYFPETWIW DLVVVDSAGV A
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rat A2M / CPAMD5 / Alpha-2-macroglobulin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat A2M / CPAMD5 / Alpha-2-macroglobulin Protein General Information | |
|---|---|
| Alternate Names | |
| A2M; CPAMD5; Alpha-2-macroglobulin; FWP007; S863-7; A2MD; CPAMD5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | A2m |
| Entrez Gene ID | 100911545 |
| Ensemble Gene ID | ENSRNOG00000028896 |
| RefSeq Protein Accession(s) | NP_036620.2 |
| RefSeq mRNA Accession(s) | NM_012488.2, XM_003749828.2 |
| UniProt ID(s) | P06238 |
| UniGene ID(s) | Rn.225884 |
| COSMIC ID Link(s) | A2m |
| KEGG Gene ID(s) | rno:100911545 |
| General Description of Recombinant Rat A2M / CPAMD5 / Alpha-2-macroglobulin Protein. | |
| Is able to inhibit all four classes of proteinases by a unique ‘trapping’ mechanism. This protein has a peptide stretch, called the ‘bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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