PDF DatasheetHuman ARNT Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant ARNT based upon sequence from: Human
Host: QP8996 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ARNT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8996.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Thr474
Amino Acid Sequence: MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNVCQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMR TSSFTFQNPY SDEIEYIICT NTNVKNSSQE PRPT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ARNT Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human ARNT Protein General Information | |
|---|---|
| Alternate Names | |
| HIF-1beta; HIF1BETA; TANGO; HIF-1-beta; HIF1-beta; HIF1B; bHLHe2; Aryl hydrocarbon receptor nuclear translocat | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ARNT |
| Entrez Gene ID | 405 |
| Ensemble Gene ID | ENSG00000143437 |
| RefSeq Protein Accession(s) | NP_001184254.1 |
| RefSeq mRNA Accession(s) | NM_001197325.1, NM_001286035.1, NM_001286036.1, NM_001668.3, NM_178427.2, XM_017001289.1 |
| UniProt ID(s) | P27540 |
| UniGene ID(s) | Hs.632446 |
| HGNC ID(s) | HGNC:700 |
| COSMIC ID Link(s) | ARNT |
| KEGG Gene ID(s) | hsa:405 |
| PharmGKB ID(s) | PA24994 |
| General Description of Recombinant Human ARNT Protein. | |
| Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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