PDF DatasheetHuman BNIP3L Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant BNIP3L based upon sequence from: Human
Host: QP9010 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) BNIP3L, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9010.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Tyr219
Amino Acid Sequence: MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human BNIP3L Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human BNIP3L Protein General Information | |
|---|---|
| Alternate Names | |
| NIX; BNIP3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-li | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BNIP3L |
| Entrez Gene ID | 665 |
| Ensemble Gene ID | ENSG00000104765 |
| RefSeq Protein Accession(s) | NP_001317420.1 |
| RefSeq mRNA Accession(s) | NM_001330491.1, NM_004331.2 |
| UniProt ID(s) | O60238 |
| UniGene ID(s) | Hs.131226 |
| HGNC ID(s) | HGNC:1085 |
| COSMIC ID Link(s) | BNIP3L |
| KEGG Gene ID(s) | hsa:665 |
| PharmGKB ID(s) | PA25395 |
| General Description of Recombinant Human BNIP3L Protein. | |
| Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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