PDF DatasheetHuman C4b-binding protein alpha chain Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant C4b-binding protein alpha chain based upon sequence from: Human
Host: QP9019 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) C4b-binding protein alpha chain, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9019.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Asn49 – Leu597
Amino Acid Sequence: NCGPPPTLSF AAPMDITLTE TRFKTGTTLK YTCLPGYVRS HSTQTLTCNS DGEWVYNTFC IYKRCRHPGE LRNGQVEIKT DLSFGSQIEF SCSEGFFLIG STTSRCEVQD RGVGWSHPLP QCEIVKCKPP PDIRNGRHSG EENFYAYGFS VTYSCDPRFS LLGHASISCT VENETIGVWR PSPPTCEKIT CRKPDVSHGE MVSGFGPIYN YKDTIVFKCQ KGFVLRGSSV IHCDADSKWN PSPPACEPNS CINLPDIPHA SWETYPRPTK EDVYVVGTVL RYRCHPGYKP TTDEPTTVIC QKNLRWTPYQ GCEALCCPEP KLNNGEITQH RKSRPANHCV YFYGDEISFS CHETSRFSAI CQGDGTWSPR TPSCGDICNF PPKIAHGHYK QSSSYSFFKE EIIYECDKGY ILVGQAKLSC SYSHWSAPAP QCKALCRKPE LVNGRLSVDK DQYVEPENVT IQCDSGYGVV GPQSITCSGN RTWYPEVPKC EWETPEGCEQ VLTGKRLMQC LPNPEDVKMA LEVYKLSLEI EQLELQRDSA RQSTLDKEL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human C4b-binding protein alpha chain Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human C4b-binding protein alpha chain Protein General Information | |
|---|---|
| Alternate Names | |
| C4BP; PRP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | C4BPA |
| Entrez Gene ID | 722 |
| Ensemble Gene ID | ENSG00000123838 |
| RefSeq Protein Accession(s) | NP_000706.1 |
| RefSeq mRNA Accession(s) | NM_000715.3, XM_005273251.1, XM_005273252.4 |
| UniProt ID(s) | P04003 |
| UniGene ID(s) | Hs.1012 |
| HGNC ID(s) | HGNC:1325 |
| COSMIC ID Link(s) | C4BPA |
| KEGG Gene ID(s) | hsa:722 |
| PharmGKB ID(s) | PA25905 |
| General Description of Recombinant Human C4b-binding protein alpha chain Protein. | |
| Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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