PDF DatasheetMouse SAMHD1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SAMHD1 based upon sequence from: Mouse
Host: QP9152 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) SAMHD1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9152.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ile425 – Phe658
Amino Acid Sequence: IDDMEAFTKL TDNIFLEVLH STDPQLSEAQ SILRNIECRN LYKYLGETQP KREKIRKEEY ERLPQEVAKA KPEKAPDVEL KAEDFIVDVI NVDYGMEDKN PIDRVHFYCK SNSKQAVRIN KEQVSQLLPE KFAEQLIRVY CKKKDGKSLD AAGKHFVQWC ALRDFTKPQD GDIIAPLITP LKWNNKTSSC LQEVSKVKTC LKF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse SAMHD1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse SAMHD1 Protein General Information | |
|---|---|
| Alternate Names | |
| Mg11; E330031J07Rik; Deoxynucleoside triphosphate triphosphohydrolase SAMH | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SAMHD1 |
| Entrez Gene ID | 56045 |
| RefSeq Protein Accession(s) | NP_001132992.1 |
| RefSeq mRNA Accession(s) | NM_001139520.1, NM_018851.3 |
| UniProt ID(s) | Q60710 |
| UniGene ID(s) | Mm.248478 |
| COSMIC ID Link(s) | SAMHD1 |
| KEGG Gene ID(s) | mmu:56045 |
| General Description of Recombinant Mouse SAMHD1 Protein. | |
| Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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