PDF DatasheetHuman HSD11B2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HSD11B2 based upon sequence from: Human
Host: QP9185 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HSD11B2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9185.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Arg405
Amino Acid Sequence: MERWPWPSGG AWLLVAARAL LQLLRSDLRL GRPLLAALAL LAALDWLCQR LLPPPAALAV LAAAGWIALS RLARPQRLPV ATRAVLITGC DSGFGKETAK KLDSMGFTVL ATVLELNSPG AIELRTCCSP RLRLLQMDLT KPGDISRVLE FTKAHTTSTG LWGLVNNAGH NEVVADAELS PVATFRSCME VNFFGALELT KGLLPLLRSS RGRIVTVGSP AGDMPYPCLG AYGTSKAAVA LLMDTFSCEL LPWGVKVSII QPGCFKTESV RNVGQWEKRK QLLLANLPQE LLQAYGKDYI EHLHGQFLHS LRLAMSDLTP VVDAITDALL AARPRRRYYP GQGLGLMYFI HYYLPEGLRR RFLQAFFISH CLPRALQPGQ PGTTPPQDAA QDPNLSPGPS PAVAR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human HSD11B2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HSD11B2 Protein General Information | |
|---|---|
| Alternate Names | |
| SDR9C3; HSD11K; HSD2; AME1; AME; Corticosteroid 11-beta-dehydrogenase isozyme | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HSD11B2 |
| Entrez Gene ID | 3291 |
| Ensemble Gene ID | ENSG00000176387 |
| RefSeq Protein Accession(s) | NP_000187.3 |
| RefSeq mRNA Accession(s) | NM_000196.3 |
| UniProt ID(s) | P80365 |
| UniGene ID(s) | Hs.1376 |
| HGNC ID(s) | HGNC:5209 |
| COSMIC ID Link(s) | HSD11B2 |
| KEGG Gene ID(s) | hsa:3291 |
| PharmGKB ID(s) | PA29477 |
| General Description of Recombinant Human HSD11B2 Protein. | |
| Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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