PDF DatasheetHuman KCND2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant KCND2 based upon sequence from: Human
Host: QP9228 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) KCND2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9228.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Val406 – Leu630
Amino Acid Sequence: VSNFSRIYHQ NQRADKRRAQ KKARLARIRA AKSGSANAYM QSKRNGLLSN QLQSSEDEQA FVSKSGSSFE TQHHHLLHCL EKTTNHEFVD EQVFEESCME VATVNRPSSH SPSLSSQQGV TSTCCSRRHK KTFRIPNANV SGSHQGSIQE LSTIQIRCVE RTPLSNSRSS LNAKMEECVK LNCEQPYVTT AIISIPTPPV TTPEGDDRPE SPEYSGGNIV RVSAL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human KCND2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human KCND2 Protein General Information | |
|---|---|
| Alternate Names | |
| KV4.2; RK5; Potassium voltage-gated channel subfamily D member | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KCND2 |
| Entrez Gene ID | 3751 |
| Ensemble Gene ID | ENSG00000184408 |
| RefSeq Protein Accession(s) | NP_036413.1 |
| RefSeq mRNA Accession(s) | NM_012281.2 |
| UniProt ID(s) | Q9NZV8 |
| UniGene ID(s) | Hs.654739 |
| HGNC ID(s) | HGNC:6238 |
| COSMIC ID Link(s) | KCND2 |
| KEGG Gene ID(s) | hsa:3751 |
| PharmGKB ID(s) | PA30030 |
| General Description of Recombinant Human KCND2 Protein. | |
| Voltage-gated potassium channel that mediates transmbrane potassium transport in excitable mbranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons . This current is activated at mbrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhytm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity . Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 . Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family mber. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochical gradient . The channel alternates between opened and closed conformations in response to the voltage difference across the mbrane . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, mbranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation . Likewise, interaction with DPP6 or DPP10 promotes expression at the cell mbrane and regulates both channel characteristics and activity . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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